Title: The Incredible Journey of TB - from Disease to Global Health Priority TB or Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. It usually affects the lungs but can also affect other parts of the body. TB has been around for centuries and has caused immense suffering and death. But, over the years, TB has also become one of the most significant global health priorities and a focus of global efforts to end epidemics. TB has been a scourge to humanity throughout history, leading to the death of millions of people. But with the advent of modern medicine, TB became curable, and by the 1960s, it was believed that TB would soon be eradicated. However, in the 1980s, TB made a major comeback, fueled by the HIV/AIDS epidemic and the development of multidrug-resistant strains. Since then, TB has become a formidable public health threat, with an estimated 10 million new cases and 1.4 million deaths annually. The World Health Organization has declared TB a global health emergency, and in 2018, the United Nations General Assembly held its first-ever high-level meeting on the disease. Efforts to combat TB have intensified over the years, and there have been significant achievements, such as the development of new and improved diagnostic tools, drugs and vaccines. There has also been a greater global commitment to ending the epidemic, with the United Nations setting a target of ending TB by 2030. But, TB remains complex and challenging to control. It is often linked to poverty, malnutrition, and overcrowding, and it disproportionately affects vulnerable populations such as children, the elderly, and people living with HIV. TB's incredible journey from an ancient disease to a modern-day global health priority underscores the crucial importance of public health measures, research, and innovation in tackling infectious diseases. While significant progress has been made in the fight against TB, much remains to be done. It is essential to continue supporting efforts to combat TB and ensure access to quality prevention, diagnosis, and treatment services for all those affected by this devastating disease.